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August 14, 2008. This pleasant 47-year-old woman is having decreasing vision since I last saw her in February. She recently had a little bit of an adjustment on her medication. She is off of her Lisinopril and on Spironolactone. She has been checked recently by her medical doctor and her blood pressure has been fine and her sugars have been fine. Her health as far as she knows is good. VISUAL ACUITY: OD 20/40, OS 20/40. IOP: OD 24, OS 23. There is 2+ nuclear sclerosis in both eyes. EXTENDED OPHTHALMOSCOPY: OD: Vertical C/D ratio is 0.1. There is extensive peripheral neovascularization. There is 2+ cystoid macular edema. There are patchy retinal hemorrhages and a moderately complete panretinal laser. OS: Vertical C/D ratio is 0.1. There is 2+ cystoid macular edema. There is peripheral neovascularization and panretinal laser. OCT SCAN: The OCT scan of the right eye shows increased macular edema in both eyes. The right eye is 377 microns and the left eye is 274 microns with a central foveal thickness, both of which are worse than last visit. Photos confirm clinical findings. FLUORESCEIN ANGIOGRAM: FA shows extensive active neovascularization in the mid periphery of each eye and leakage of fluorescein in the macula in the late frames of both eyes. IMPRESSION: 1. CYSTOID MACULAR EDEMA – BOTH EYES 2. PROLIFERATIVE DIABETIC RETINOPATHY – BOTH EYES 3. REACTIVATION OF PERIPHERAL NEOVASCULARIZATION DESPITE HEAVY PANRETINAL LASER DISCUSSION: I explained to the patient that I am concerned about the macular edema and the active neovascularization in her eyes. It is now known that the vascular endothelial growth factor, which is the cause of the neovascularization, also causes increased macular lesions and I suspect her macular edema is more due to increased VEGF levels in her eyes than microaneurysms. The angiogram showed almost no focal areas of leakage in the macula that would be amenable to laser. I suggested we try supplementing panretinal laser in hopes of decreasing the VEGF load in the eyes and decreasing the macular edema. I added panretinal laser to the right eye today. She will return for an evaluation in a few weeks for probable treatment in the left eye. I will also send a note to her medical doctor to see if there is anything that could be done for her systemically. If her macular edema does not subside reasonably quickly, intravitreal Avastin would probably do the trick. Intravitreal Kenalog is also helpful but she said she has a concern about her being a glaucoma suspect and also since she is phakic, her cataracts would probably worsen with the steroids.

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Proliferative Diabetic Retinopathy both eyes Type I Diabetic for 25 years163 views47-year-old woman with diabetes for 25 years and decreased vision for 3 months. OD 20/40, OS 20/4000000
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Proliferative Diabetic Retinopathy both eyes Type I Diabetic for 25 years234 views47-year-old woman with diabetes for 25 years and decreased vision for 3 months. OD 20/40, OS 20/4000000
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Proliferative Diabetic Retinopathy both eyes Type I Diabetic for 25 years133 views47-year-old woman with diabetes for 25 years and decreased vision for 3 months. OD 20/40, OS 20/4000000
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Proliferative Diabetic Retinopathy both eyes Type I Diabetic for 25 years111 views47-year-old woman with diabetes for 25 years and decreased vision for 3 months. OD 20/40, OS 20/4000000
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Proliferative Diabetic Retinopathy both eyes Type I Diabetic for 25 years80 views47-year-old woman with diabetes for 25 years and decreased vision for 3 months. OD 20/40, OS 20/4000000
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Proliferative Diabetic Retinopathy both eyes Type I Diabetic for 25 years75 views47-year-old woman with diabetes for 25 years and decreased vision for 3 months. OD 20/40, OS 20/4000000
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Proliferative Diabetic Retinopathy both eyes Type I Diabetic for 25 years74 views47-year-old woman with diabetes for 25 years and decreased vision for 3 months. OD 20/40, OS 20/4000000
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Proliferative Diabetic Retinopathy both eyes Type I Diabetic for 25 years88 views47-year-old woman with diabetes for 25 years and decreased vision for 3 months. OD 20/40, OS 20/4000000
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Proliferative Diabetic Retinopathy both eyes Type I Diabetic for 25 years113 views47-year-old woman with diabetes for 25 years and decreased vision for 3 months. OD 20/40, OS 20/4055555
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Proliferative Diabetic Retinopathy both eyes Type I Diabetic for 25 years49 views47-year-old woman with diabetes for 25 years and decreased vision for 3 months. OD 20/40, OS 20/4000000
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Proliferative Diabetic Retinopathy both eyes Type I Diabetic for 25 years51 views47-year-old woman with diabetes for 25 years and decreased vision for 3 months. OD 20/40, OS 20/4000000
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Proliferative Diabetic Retinopathy both eyes Type I Diabetic for 25 years53 views47-year-old woman with diabetes for 25 years and decreased vision for 3 months. OD 20/40, OS 20/4000000
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Proliferative Diabetic Retinopathy both eyes Type I Diabetic for 25 years58 views47-year-old woman with diabetes for 25 years and decreased vision for 3 months. OD 20/40, OS 20/4000000
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Proliferative Diabetic Retinopathy both eyes Type I Diabetic for 25 years54 views47-year-old woman with diabetes for 25 years and decreased vision for 3 months. OD 20/40, OS 20/4000000
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Proliferative Diabetic Retinopathy both eyes Type I Diabetic for 25 years67 views47-year-old woman with diabetes for 25 years and decreased vision for 3 months. OD 20/40, OS 20/4000000
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Proliferative Diabetic Retinopathy both eyes Type I Diabetic for 25 years60 views47-year-old woman with diabetes for 25 years and decreased vision for 3 months. OD 20/40, OS 20/4000000
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Proliferative Diabetic Retinopathy both eyes Type I Diabetic for 25 years53 views47-year-old woman with diabetes for 25 years and decreased vision for 3 months. OD 20/40, OS 20/4000000
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Proliferative Diabetic Retinopathy both eyes Type I Diabetic for 25 years60 views47-year-old woman with diabetes for 25 years and decreased vision for 3 months. OD 20/40, OS 20/4000000
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Proliferative Diabetic Retinopathy both eyes Type I Diabetic for 25 years51 views47-year-old woman with diabetes for 25 years and decreased vision for 3 months. OD 20/40, OS 20/4000000
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Proliferative Diabetic Retinopathy both eyes Type I Diabetic for 25 years52 views47-year-old woman with diabetes for 25 years and decreased vision for 3 months. OD 20/40, OS 20/4000000
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Proliferative Diabetic Retinopathy both eyes Type I Diabetic for 25 years67 views47-year-old woman with diabetes for 25 years and decreased vision for 3 months. OD 20/40, OS 20/4000000
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Proliferative Diabetic Retinopathy both eyes Type I Diabetic for 25 years56 views47-year-old woman with diabetes for 25 years and decreased vision for 3 months. OD 20/40, OS 20/4000000
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Proliferative Diabetic Retinopathy both eyes Type I Diabetic for 25 years104 views47-year-old woman with diabetes for 25 years and decreased vision for 3 months. OD 20/40, OS 20/4000000
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Proliferative Diabetic Retinopathy both eyes Type I Diabetic for 25 years100 views47-year-old woman with diabetes for 25 years and decreased vision for 3 months. OD 20/40, OS 20/4000000
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Proliferative Diabetic Retinopathy both eyes Type I Diabetic for 25 years153 views47-year-old woman with diabetes for 25 years and decreased vision for 3 months. OD 20/40, OS 20/4000000
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August 14, 2008. This pleasant 47-year-old woman is having decreasing vision since I last saw her in February. She recently had a little bit of an adjustment on her medication. She is off of her Lisinopril and on Spironolactone. She has been checked recently by her medical doctor and her blood pressure has been fine and her sugars have been fine. Her health as far as she knows is good. VISUAL ACUITY: OD 20/40, OS 20/40. IOP: OD 24, OS 23. There is 2+ nuclear sclerosis in both eyes. EXTENDED OPHTHALMOSCOPY: OD: Vertical C/D ratio is 0.1. There is extensive peripheral neovascularization. There is 2+ cystoid macular edema. There are patchy retinal hemorrhages and a moderately complete panretinal laser. OS: Vertical C/D ratio is 0.1. There is 2+ cystoid macular edema. There is peripheral neovascularization and panretinal laser. OCT SCAN: The OCT scan of the right eye shows increased macular edema in both eyes. The right eye is 377 microns and the left eye is 274 microns with a central foveal thickness, both of which are worse than last visit. Photos confirm clinical findings. FLUORESCEIN ANGIOGRAM: FA shows extensive active neovascularization in the mid periphery of each eye and leakage of fluorescein in the macula in the late frames of both eyes. IMPRESSION: 1. CYSTOID MACULAR EDEMA – BOTH EYES 2. PROLIFERATIVE DIABETIC RETINOPATHY – BOTH EYES 3. REACTIVATION OF PERIPHERAL NEOVASCULARIZATION DESPITE HEAVY PANRETINAL LASER DISCUSSION: I explained to the patient that I am concerned about the macular edema and the active neovascularization in her eyes. It is now known that the vascular endothelial growth factor, which is the cause of the neovascularization, also causes increased macular lesions and I suspect her macular edema is more due to increased VEGF levels in her eyes than microaneurysms. The angiogram showed almost no focal areas of leakage in the macula that would be amenable to laser. I suggested we try supplementing panretinal laser in hopes of decreasing the VEGF load in the eyes and decreasing the macular edema. I added panretinal laser to the right eye today. She will return for an evaluation in a few weeks for probable treatment in the left eye. I will also send a note to her medical doctor to see if there is anything that could be done for her systemically. If her macular edema does not subside reasonably quickly, intravitreal Avastin would probably do the trick. Intravitreal Kenalog is also helpful but she said she has a concern about her being a glaucoma suspect and also since she is phakic, her cataracts would probably worsen with the steroids.